Applications of glycobiology: biological and immunological effects of a chemically modified amylose-derivative
Lipopolysaccharide structure and biological activity from the cystic fibrosis pathogens
Burkholderia cepacia complex
Synthesis of bacterial carbohydrate surface structures containing Kdo and
glycero- D- manno-heptose linkages
Posttranslational sialylation and its impact on leukocyte recruitment during inflammation
Glycoengineering of protein-based therapeutics
Congenital Disorders of Glycosylation (CDG): from glycoproteins to patient care
Bladder cancer–glycosylation insights
Pseudomonas bacteria: novel approaches for protein expression, assay of enzymes, fructooligosaccharides and heterooligofructans
Recent advances on the application of NMR methods to study the conformation and recognition properties of carbohydrates
Glycosidase inhibitors: versatile tools in glycobiology
An overview of key routes for the transformation of sugars into carbasugars and related compounds
Multivalent glycoconjugates in medicinal chemistry
Glycotransporters for gene delivery
Furanose-based templates in the chemoselective generation of molecular diversity
Synthesis of carbohydrate-based artificial siderophores and their biological applications
About this book
In this volume, glycochemistry and glycobiology have been combined to demonstrate the contribution of organic chemistry, modern analytics, biological and biochemical expertise to the increasingly important field of glycomincs. A polysaccharide immunomodulator with therapeutic implications, carbohydrate vaccines, new findings emphasizing the influence of carbohydrate decoration on the regulation of inflammatory response and new therapeutic approaches in the treatment of acute and chronic inflammatory diseases, recent approachesin the treatment of acute and chronic inflammatory diseases, recent progress on glycoengineering based on a glycosylation, and key aspects of the glycosylation changes associated with bladder cancer are amongst the subjects presented in this volume.
The contribution of glycochemistry to innovation in glycosciences is shown with chapters covering highly functionalized exo-glycals for the generation of molecular diversity in a chemoselective manner, imino sugar glycosidase inhibitors, carbasugars, multivalent glycoconjugates, including glycodendrimers, glyconanotubes, and glyconanoparticles, and their uses in medicinal chemistry, as well as artificial saccharide-based and saccharide functionalized gene delivery systems. Siderphores based on monosaccharides (which have proven effective for Gram-negative bacteria and mycobacteria), and the so-called smart materials, (which can modulate and control cell behaviour), complete the volume.
Volume 38 of Carbohydrate Chemistry - Chemical and Biological Apporaches contains contributions ranging from glycochemistry to glycobiology. This collection demonstrates in a meaningful way how the interdisciplinary approach of an international glyconetwork can advance the field of carbohydrate research in Europe and worldwide.
Amelia Pilar Rauter is Head of Carbohydrate Chemistry Group in the Chemistry and Biochemistry department of the University of Lisbon, Portugal. Thisbe K Lindhorst is Professor of Organic and Bioorganic Chemistry at the University of Kiel, Germany.