General Overview of Fast and High-resolution Approaches in Liquid Chromatography
Instrumentation and Columns for UHPLC Separations
Method Transfer Between Conventional HPLC and UHPLC
Comparison of the Performance of Totally Porous and Core-shell Particles
Shell Particle and UHPLC Technologies for Fast Analysis of Polar Compounds in the HILIC Mode
UHPLC/MS Coupling: How to Select a Suitable Configuration?
UHPLC for the Determination of Physicochemical Parameters in Drug Discovery
Ultra-high Pressure Liquid Chromatography coupled to Mass Spectrometry in Doping Control Analysis
UHPLC-MS for Multi-residue Screening of Pharmaceuticals in Environmental Samples
Application of UHPLC-MS to Metabolomic/metabonomic Studies in Man
About this book
Since its commercial introduction in 2004, UHPLC (Ultra-High Performance Liquid Chromatography) has begun to replace conventional HPLC in academia and industry and interest in this technique continues to grow. Both the increases in speed and resolution make this an attractive method; particularly to the life sciences and more than 1500 papers have been written on this strongly-evolving topic to date.
Davy Guillarme gained his PhD in analytical chemistry from the University of Lyon (France) in 2004. He is now lecturer at the School of Pharmaceutical Sciences, University of Geneva (Switzerland). He is working mainly on the development of new approaches to perform ultra-fast and high resolution separations in liquid chromatography. He is also interested in the coupling of these strategies with alternative detection modes, particularly mass spectrometry. Jean-Luc Veuthey obtained his PhD in analytical chemistry from the University of Geneva (Switzerland) in 1987. He is now full professor at the School of Pharmaceutical Sciences, University of Geneva (Switzerland). His interests include the development of LC and CE hyphenated to several detection modes for the analysis of drugs and metabolites. Sample preparation and validation of the procedures are also particularly studied in his laboratory.