Role of Fluorine in Weak Interactions in Co-crystals
Polymorph Prediction of Small Organic Molecules, Co-crystals and Salts
Shape and Polarity in Co-crystal Formation: Database Analysis and Experimental Validation
Role of Co-crystals in the Pharmaceutical Development Continuum
Application of Mechanochemistry in the Synthesis and Discovery of New Pharmaceutical Forms: Co-crystals, Salts and Coordination Compounds
Co-crystallization in Solution and Scale-up Issues
Analytical Techniques and Strategies for Salt/Co-crystal Characterization
Co-crystal Solubility and Thermodynamic Stability
Application of Phase Diagrams in Co-crystal Search and Preparation
Co-crystals: Commercial Opportunities and Patent Considerations
Concluding Remarks using Piracetam as a Learning Model
Monographs of most Frequent Co-Crystal Formers
About this book
From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, à) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.
Johan Wouters is Professor at the Department of Chemistry and a Member of the Drug Design Discovery Center at the University of Namur, Belgium. He is also a teacher in general chemistry, crystallography and structure-based drug design and is the author of about 120 papers. Luc Quere is at UCB Pharma.