Dipeptidyl Peptidases: Substrates and Therapeutic Targeting in Human Health and Disease
The Metalloproteases Meprin
α and β: Pathophysiological Roles in Inflammation, Cardiovascular Disease, Cancer, and Fibrosis
Glutamate Carboxypeptidase II as a Therapeutic Target
The Role of Proteolytically Inactive Serine Proteases from Sarcoptes scabiei in Complement Evasion
Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy
Discovery of the Cysteine Protease Cathepsin B as a Drug Target for Alzheimer's Disease
Plasmodium falciparum Neutral Aminopeptidases: Development of Novel Anti-Malarials by Understanding Enzyme Structure
Blood-Feeding Human Hookworm Proteases
Pharmacological Targeting of Human Tissue Kallikrein-Related Peptidases
Structural Mechanisms of Inactivation in Proteolytically Inactive Serine Proteases from
The Aspartic Proteinases from the Malaria Parasite: Structure and Function of the Plasmepsins
About this book
This book provides vital information on a class of enzymes that have emerged as key drug targets in a number of human diseases, including HIV/AIDS, Hypertension, Cancer, and Alzheimer's disease. There is a gap in information due to the lack of recent international meetings on this subject and, thus, no recent summaries of current research have emerged. The book contains up-to-date information, especially with the genomics revolution of recent years, and includes new proteomics techniques. The story of this enzyme family also includes the most significant efforts in computer-aided drug discovery and structure-based drug design. With contributions from experts in the field, the book is edited by the previous President of the International Proteolysis Society, whose academic career in the field has spanned 35 years.
Ben M Dunn is a Distinguished Professor of Biochemistry & Molecular Biology at the Department of Biochemistry & Molecular Biology, University of Florida, USA. He is also an NIH-funded Investigator and is currently supported by a MERIT award for the NIAID. He was President of the International Proteolysis Society from 2003-2005 and is currently President of the American Peptide Society.