Tandem and Clustered Lesions from Radicals in Nucleic Acids from a Single Initial Chemical Event
Oxidative DNA Damage and Repair in G-quadruplexes
Oxidatively Induced DNA Damage: Mechanisms and Measurement
DNA–Protein Cross-links: Formation, Genotoxicity and Repair
Substrate Specificities of DNA Glycosylases In Vitro and In Vivo
Special Problems for Base Excision Repair in Coping with Oxidatively-induced DNA Damage
Genomic Uracil in Biology, Immunity and Cancer
Modulation of DNA Glycosylase Activities via Small Molecules
DNA Repair in the Development of Human Diseases and Therapy
Subject Index
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About this book
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.