CHAPTER 2
DNA-encoded Chemistry and Its Use in Discovering Chemical Probes
Anthony D. Keefe
Pages 14 - 38
CHAPTER 3
Computational Methods for the Discovery of Chemical Probes
G. Poda and V. Tanchuk
Pages 39 - 68
CHAPTER 6
Discovery and Use of Natural Products and Derivatives as Chemical Probes
Masaki Kita and Hideo Kigoshi
Pages 124 - 149
CHAPTER 9
Chemical Probes to Control RNA Function
Liberty François-Moutal, Victor Miranda, Michael Sandino and May Khanna
Pages 214 - 246
CHAPTER 10
Assays to Characterize the Cellular Pharmacology of a Chemical Probe
Jakub Stefaniak, Sébastien R. G. Galan and Kilian V. M. Huber
Pages 247 - 275
Subject Index
Pages 320 - 325
Publication details
Print publication date
26 Nov 2020
Copyright year
2021
Print ISBN
978-1-78801-589-9
PDF eISBN
978-1-83916-074-5
ePub eISBN
978-1-83916-084-4
About this book
Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.