Phenotypic Drug Discovery

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

From the book series:
Drug Discovery

Phenotypic Drug Discovery Editors: Beverley Isherwood, Angelique Augustin

Front Matter

Preface

Phenotypic Drug Discovery: A Personal Perspective

Contents

Phenotypic Drug Discovery: History, Evolution, Future

Development and Validation of Disease Assays for Phenotypic Screening

The Development and Use of Protein and Protein-affinity Libraries for Phenotypic Screening

CRISPR/Cas-based Functional Genomic Approaches to Phenotypic Screening

Contemporary Techniques for Target Deconvolution and Mode of Action Elucidation

Artificial Intelligence as an Enabler for Phenotypic Drug Discovery

Public–Private Partnerships to Advance Phenotypic Drug Discovery

Identification of a Novel Class of Small Molecules for Spinal Muscular Atrophy Through High-throughput Phenotypic Screening

Antibody-based Phenotypic Screening – the Discovery of Oleclumab (MEDI9447)

Use of Phenotypic Screening in Mice in the Development of a Novel Non-D2-Receptor-Targeting Drug for the Treatment of Schizophrenia

Phenotypic Screening for Drug Discovery in Tuberculosis

Why an In Vivo Screening Platform Covering Broad Therapeutic Spectrum is an Ideal Tool for Drug Repositioning: Illustrated by Discovery of a Novel Class of Insulin Sensitizers

Phenotypic Screen Leads to Identification of Novel Post-transcriptional Regulation Machinery for HBV

Subject Index

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