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Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology Editors: Hilmar Weinmann, Craig Crews


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This book contains 359 pages.

Publication details


Print publication date
08 Oct 2020
Copyright year
2021
Print ISBN
978-1-78801-686-5
PDF eISBN
978-1-83916-069-1
ePub eISBN
978-1-83916-077-6

About this book

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

From the book series:
Drug Discovery