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The Discovery and Utility of Chemical Probes in Target Discovery Editors: Paul Brennan, Saleta Vazquez Rodriguez

About this book

Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.

From the book series:
Chemical Biology

Book content

  • Introduction to Chemical Probes
  • DNA-Encoded Chemistry and its use to Discover Chemical Probes
  • Computational Methods for the Discovery of Chemical Probes
  • Best Practices for Design and Characterization of Covalent Chemical Probes
  • Cyclic Peptides as Chemical Probes
  • Discovery and Use of Natural Products and Derivatives as Chemical Probes
  • Targeted Protein Degradation Chemical Probes
  • Chemical Probes for Kinases
  • Chemical Probes to Control RNA Function
  • Assays to Characterize Cellular Pharmacology of a Chemical Probe
  • Chemical Probes in Cellular Assays for Target Validation and Screening in Neurodegeneration

The print version of this book is planned for release on 26 November 2020. Information about this book is subject to change without notice.

Pre-order hardback £159.00 *
* Exclusive of taxes
This book contains 300 pages.

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ePub eISBN