Best Practices for Design and Characterization of Covalent Chemical Probes
Discovery and Use of Natural Products and Derivatives as Chemical Probes
Chemical Probes to Control RNA Function
Assays to Characterize the Cellular Pharmacology of a Chemical Probe
Chemical Probes in Cellular Assays for Target Validation and Screening in Neurodegeneration
About this book
Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.