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Inhibitors of Protein–Protein Interactions: Small Molecules, Peptides and Macrocycles Editor: Ali Tavassoli



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This book contains 342 pages.

Publication details


Print publication date
07 Dec 2020
Copyright year
2021
Print ISBN
978-1-78801-569-1
PDF eISBN
978-1-83916-067-7
ePub eISBN
978-1-83916-070-7

About this book

Protein–protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.

From the book series:
Chemical Biology