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Anti-fibrotic Drug Discovery Editors: Jehrod Brenneman, Malliga R Iyer

About this book

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

From the book series:
Drug Discovery

Book content

  • TGFß Signalling in Fibrosis
  • Targeting Integrins in Fibroproliferative Disease
  • Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor (FXR) Activators
  • Autotaxin Inhibitors in Fibrosis
  • Inhibition of LOXL2 and Other Lysyl Oxidase (Like) Enzymes: Intervention at the Core of Fibrotic Pathology
  • Galectin-3 Involvement in Fibrotic Diseases
  • The Emerging Role of CXCR4 in IPF
  • BH3 Mimetic Drugs for Anti-Fibrotic Therapy
  • Intratumoral Fibrosis: Emerging Concepts and Therapeutic Opportunities
  • Targeting Fibroblasts in Cancer and Fibrosis

The print version of this book is planned for release on 23 March 2020. Information about this book is subject to change without notice.

Pre-order hardback £169.00 *
* Exclusive of taxes
This book contains 340 pages.

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