Preparation Methods for Tissue/Organ-derived dECMs – Effects on Cell Removal and ECM Changes
Immune Responses to Decellularized Matrices
Decellularized Extracellular Matrix as Bioink for 3D-Bioprinting
Mechanical Property Tunable dECM and Their Regenerative Applications
Use of Small Intestinal Submucosa dECM in Tissue Engineering and Regenerative Medicine
Small-diameter Acellular Vascular Grafts: From Basic Research to Clinical Application
Engineering an Endocrine Neo-Pancreas
Decellularized Extracellular Matrix for the Regulation of Stem Cell Differentiation
Extracellular Matrix in Peripheral Nerve Regeneration
Subject Index
Publication details
About this book
The extracellular matrix (ECM) supports cells and regulates various cellular functions in our body. The native ECM promises to provide an excellent scaffold for regenerative medicine. In order to use the ECM as a scaffold in medicine, its cellular fractions need to be removed while retaining its structural and compositional properties. This process is called decellularization, and the resulting product is known as the decellularized extracellular matrix (dECM). This book focuses on the sources of dECM and its preparation, characterization techniques, fabrication, and applications in regenerative medicine and biological studies. Using this book, the reader will gain a good foundation in the field of ECM decellularization complemented with a broad overview of dECM characterization, ranging from structural observation and compositional assessment to immune responses against dECM and applications, ranging from microfabrication and 3D-printing to the application of tissue-derived dECM in vascular grafts and corneal tissue engineering etc. The book closes with a section dedicated to cultured cell dECM, a complementary technique of tissue-derived dECM preparation, for application in tissue engineering and regenerative medicine, addressing its use in stem cell differentiation and how it can help in the study of the tumor microenvironment as well as in clinical trials of peripheral nerve regeneration.