Nanoparticle–Protein Corona

Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration.

This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.

From the book series:
Issues in Toxicology

Nanoparticle–Protein Corona: Biophysics to Biology Editors: Ashutosh Kumar, Alok Dhawan

Front Matter

Preface

Contents

Nanoparticle–Protein Corona Complex: Composition, Kinetics, Physico–Chemical Characterization, and Impact on Biomedical Applications

Biological Significance of the Nanoparticles Protein Corona

Factors Affecting a Nanoparticle's Protein Corona Formation

NP–Protein Corona Interaction: Characterization Methods and Analysis

An Analytical Approach to Investigate Nanoparticle–Protein Corona Complexes

Impact of Nanoparticle–Protein Interactions on Biological Assays

Computer Simulations for Understanding Nanoparticle-biomolecule Corona Formation

In Silico Approaches to Design and Characterize Peptide-based Nanostructures

Nanomaterial–Blood Interactions: A Biomedical Perspective

The Protein Corona: Applications and Challenges

Subject Index

Supplementary files

Publication details

About this book