The Micronucleus Assay in Toxicology Editors: Siegfried Knasmüller, Michael Fenech
Mechanisms by Which Genotoxins Cause Micronuclei and Other Nuclear Anomalies
The Fate of Micronuclei and Micronucleated Cells
The Cytokinesis-block Micronucleus Cytome Assay in Human Lymphocytes
Micronuclei in the Bone Marrow Cells of Rodents
The In Vitro Micronucleus Assay with Rodent Hepatocytes
Micronucleus Assays with Human Lymphocytes for in Vitro Genetic Toxicology Testing
The Piscine Erythrocyte Micronucleus Cytome Assay
Automated Identification and Scoring of Micronuclei
Micronucleus Assay: Epidemiological and Statistical Issues
Effects of Tobacco Smoking on Micronucleus Frequency
Khat, Betel, Coca and Tobacco Chewing: Genotoxic Effects in Micronucleus Assays
Electromagnetic Fields and Micronuclei
Ionising Radiation Exposure Biodosimetry Using the Lymphocyte Cytokinesis-block Micronucleus Cytome Assay
Heavy Metals II (Arsenic, Chromium, Nickel, Vanadium) and Micronuclei
Pesticide Exposure and Its Effects on Micronucleus Frequency
Petroleum, Its Derivatives and Micronuclei
Butadiene and Its Effects on Micronucleus Frequency
The Effect of Dust, Asbestos and Other Fibers on DNA Damage Measured Using the Micronucleus Assay
Use of Micronucleus Assays to Measure DNA Damage Caused by Coal Dust and Ash
The Micronucleus Assay as a Cytogenetic Biomarker of Ethylene Oxide Exposure
Micronucleus Induction by Exposure to Vinyl Chloride
Subject Index
Supplementary files
Publication details
- Print publication date
- 26 Jul 2019
- Copyright year
- 2019
- Print ISBN
- 978-1-78801-134-1
- PDF eISBN
- 978-1-78801-360-4
- ePub eISBN
- 978-1-78801-849-4
About this book
Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods which are currently used for the analyses of micronuclei in different types of cells in human in vivo biomonitoring studies, routine in vivo tests with rodents, in vitro studies with human and mammalian cells, environmental monitoring with invertebrates and vertebrates such as molluscs, fish and, also, in plant bioassays. Moreover, this book also focuses on the use of the micronucleus technique in other research areas, including the detection of DNA damage caused by important groups of genotoxic carcinogens (heavy metals, industrial chemicals, cytotoxic drugs, pesticides, ionising radiation, etc.) as well as study designs, statistical analyses, international regulatory guidelines, and the development of automated scoring devices for this assay. This book will serve as both, a reference and a guide to students, and investigators in biomedical, biochemical and pharmaceutical sciences interested in gaining a better understanding of the biology of micronuclei and their application in measuring DNA damage caused by natural or man-made genotoxins.