Looking Beyond the Traditional Idea of Glutathione Peroxidase Mimics as Antioxidants
Synthesis of Organoselenium Compounds with Potential Biological Activities
The Relevant Chemistry of Imidazoline-2-selone Donors with Potential Biological Applications
Organoselenium Cations: Structures, Reactivity and Applications
Organoselenide Fluorophores for Probing Reactive Oxygen Species and Heavy Metals
Non-bonded Selenium⋯Heteroatom Interactions in Selenoenzyme Glutathione Peroxidase and Mimics
Carbohydrate-derived Organoselenium Compounds: Synthesis and Application in the Structural Analysis of Biomolecules
Reaction of Selenium Compounds with Reactive Oxygen Species and the Control of Oxidative Stress
Reactive Selenium Species: Redox Modulation, Antioxidant, Antimicrobial and Anticancer Activities
Ebselen and Thioredoxin Systems in Human Health, Disease and Therapeutic Potential
History and Development of Selenium-based Radioprotectors: Distinctions between the Inorganic and Organic Forms
Toxicology and Anticancer Activity of Synthetic Organoselenium Compounds
Metabolism of Selenium/Selenocystine and Their Roles in the Prevention and Treatment of Human Cancer
Organoselenium Compounds as Cancer Therapeutic Agents
About this book
Organoselenium shows incredible promise in medicine, particularly cancer therapy. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications.
Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how organoselenium compound toxicity, redox properties and specificity can be further tuned. The second section explains the biophysics and biochemistry of organoselenium compounds, as well as selenoproteins. The final section closes with several chapters devoted to therapeutic and medicinal applications of organoselenium compounds, covering radioprotectors, anticancer agents and antioxidant behaviour.
With contributions from leading global experts, this book covers recent advances in the field and is an ideal reference for those researching organoselenium compounds.