Modulation of Biological Targets Using Allosteric Ligands: Food for Thought
Targeting Catalytic and Non-Catalytic Functions of Protein Kinases
Molecular Biology Techniques Applied to GPCR Allosteric and Biased Ligands
Examining Allosterism in a Dimeric G-Protein-Coupled Receptor Context
A Unifying Approach to the Duality of “Energetic”
Versus “Conformational” Formulations of Allosteric Coupling: Mechanistic Implications for GPCR Allostery
4 PET Ligands as Enablers of Target Biology Understanding
Allosteric Modulators of Adenosine, P2Y and P2X Receptors
Positive Allosteric Modulators of G-Protein-Coupled Receptors that Act
via Covalent Mechanisms of Action
Mechanism of Action of a GluN2C- and GluN2D-Selective NMDA Receptor Positive Allosteric Modulator
Development of AMPA Receptor Modulators as Cognition Enhancers
Allosteric Modulation of Neuronal Nicotinic Acetylcholine Receptors
Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target
Allosteric Inhibition of Abl Kinase
About this book
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery.
Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future.
This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.