Introduction: General Aspects of the Chemical Biology of Glycoproteins
Chemical Biology of Protein O-Glycosylation
Chemical Biology of O-GlcNAc Glycosylation
Chemical Synthesis and Engineering of N-Linked Glycoproteins
Chemoenzymatic Synthesis of N-Glycans
Towards Synthesis of Heparan Sulfate Glycopeptides and Proteoglycans
Chemoenzymatic Synthesis of Low-Molecular-Weight Heparin and Heparan Sulfate
Synthetic Studies of GPI-Anchored Peptides, Glycopeptides, and Proteins
Chemical Approaches to Image Protein Glycosylation
Targeting Glycans of HIV Envelope Glycoproteins for Vaccine Design
Design, Synthesis and Evaluation of Mucin Glycopeptide Based Cancer Vaccine
About this book
Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions.
Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.