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The Comet Assay in Toxicology


Preliminary content
Chapter 1

The Comet Assay: A Versatile Tool for Assessing DNA Damage

Mahima Bajpayee, Ashutosh Kumar and Alok Dhawan
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Pages 1 - 64
Chapter 2

High-throughput Measurement of DNA Breaks and Oxidised Bases with the Comet Assay

Amaya Azqueta, Isabele Campos Costa-Amaral and Andrew R. Collins
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Pages 65 - 92
Chapter 3

Microplate-based Comet Assay

Elizabeth D. Wagner and Michael J. Plewa
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Pages 93 - 111
Chapter 4

The Use of Higher Plants in the Comet Assay

Tomas Gichner, Irena Znidar, Elizabeth D. Wagner and Michael J. Plewa
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Pages 112 - 133
Chapter 5

Methods for Freezing Blood Samples at −80 °C for DNA Damage Analysis in Human Leukocytes

Narendra P. Singh and Henry C. Lai
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Pages 134 - 142
Chapter 6

Development and Applications of the Comet-FISH Assay for the Study of DNA Damage and Repair

Valerie J. Mckelvey-Martin and Declan J. Mckenna
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Pages 143 - 163
Chapter 7

Detection of DNA Damage in Different Organs of the Mouse

Ritesh Kumar Shukla, Mahima Bajpayee and Alok Dhawan
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Pages 164 - 176
Chapter 8

Detection of DNA Damage in Drosophila

Ashutosh Kumar, Mahima Bajpayee and Alok Dhawan
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Pages 177 - 192
Chapter 9

The Comet Assay: Clinical Applications

M. M. Piperakis, K. Kontogianni and S. M. Piperakis
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Pages 193 - 237
Chapter 10

Applications of the Comet Assay in Human Biomonitoring

Andrew R. Collins and Maria Dusinska
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Pages 238 - 263
Chapter 11

Comet Assay in Human Biomonitoring

Mahara Valverde and Emilio Rojas
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Pages 264 - 313
Chapter 12

Use of Single-cell Gel Electrophoresis Assays in Dietary Intervention Trials

Armen Nersesyan, Christine Hoelzl, Franziska Ferk, Miroslav Mišík, Halh Al-Serori, Tahereh Setayesh and Siegfried Knasmueller
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Pages 314 - 353
Chapter 13

The Application of the Comet Assay in Aquatic Environments

G. Frenzilli, T. P. Bean and B. P. Lyons
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Pages 354 - 368
Chapter 14

The Alkaline Comet Assay in Prognostic Tests for Male Infertility and Assisted Reproductive Technology Outcomes

Sheena E. M. Lewis and Ishola M. Agbaje
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Pages 369 - 389
Chapter 15

The Comet Assay in Sperm—Assessing Genotoxins in Male Germ Cells

Adolf Baumgartner, Aftab Ali, Charmaine Normington and Diana Anderson
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Pages 390 - 456
Chapter 16

Genotoxic Effects in Peripheral Blood and Sperm in Humans in Healthy Individuals and Those with Disease States

Diana Anderson, Adolf Baumgartner and Mojgan Najafzadeh
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Pages 457 - 476
Chapter 17

Application of the Comet Assay in Nanotoxicology

Maria Dusinska, Elise Rundén-Pran, Naouale El Yamani, Lise M. Fjellsbø and Andrew Collins
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Pages 477 - 497
Chapter 18

Comet Assay – Protocols and Testing Strategies

Andreas Hartmann and Günter Speit
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Pages 498 - 514
Chapter 19

Imaging and Image Analysis in the Comet Assay

Mark Browne
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Pages 515 - 550
Chapter 20

Statistical Analysis of Comet Assay Data

David P. Lovell
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Pages 551 - 580

Subject Index
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Pages 581 - 590

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Publication details

https://doi.org/10.1039/9781782622895
Print publication date: 07 Oct 2016
Copyright year: 2017
Print ISBN: 978-1-78262-287-1
PDF eISBN: 978-1-78262-289-5
ePub eISBN: 978-1-78262-915-3