Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymes
Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyond
Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases
The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing
Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA
The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenases
2-Oxoglutarate-Dependent Hydroxylases Involved in DNA Base J (β-D-Glucopyranosyloxymethyluracil) Synthesis
Dioxygenases of Carnitine Biosynthesis: 6-N-Trimethyllysine and γ-Butyrobetaine Hydroxylases
Phytanoyl-CoA Hydroxylase: A 2-Oxoglutarate-Dependent Dioxygenase Crucial for Fatty Acid Alpha-Oxidation in Humans
Role of 2-Oxoglutarate-Dependent Oxygenases in Flavonoid Metabolism
2-Oxoglutarate-Dependent Oxygenases of Cephalosporin Synthesis
Recent Advances in the Structural and Mechanistic Biology of Non-Haem Fe(II), 2-Oxoglutarate and O2-Dependent Halogenases
4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase: 2-Oxo Acid-Dependent Oxygenases of Importance to Agriculture and Medicine
About this book
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia.
This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits.
The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.