High-throughput X-ray crystallography for drug discovery
Trawling the genome for G protein-coupled receptors: The importance of integrating bioinformatic approaches
Virtual screening of virtual libraries – an efficient startegy for lead generation
The impact of physical organic chemistry on the control of drug-like properties
Mutagenesis and modelling highlight the critical nature of the TM2-loop-TM3 region of biogenic amine GPCRs
Computational vaccine design
About this book
Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others. University and pharmaceutical company libraries will also benefit from having a copy on their shelves.