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Chapter 24

Tumour-associated glycopeptide antigens and their modification in anticancer vaccines

Glycopeptide antigens are obtained by solid-phase glycopeptide synthesis using fluorenylmethoxycarbonyl-(Fmoc)-protected O-glycosyl threonine and serine building blocks representing the tumour-associated mucin carbohydrate antigens. Conjugation of the synthetic mucin glycopeptide antigens with T-cell epitope peptides and/or immune stimulating lipopeptides affords fully synthetic two- and three-component vaccines useful for immunization of mice. Conjugates of the synthetic tumour-associated glycopeptide antigens with carrier proteins, in particular with tetanus toxoid, proved to be potent antitumour vaccines inducing high titres of IgG antibodies, which strongly bind to breast tumour cells. Mimics of the carbohydrate antigens within these glycopeptides also result in efficient vaccines as long as the carbohydrate structure remains closely related to the natural tumour-associated carbohydrate antigen.

Publication details

Print publication date
25 Mar 2014
Copyright year
Print ISBN
ePub eISBN
From the book series:
SPR - Carbohydrate Chemistry