Today about 70% of all medications administered are as tablets. Present-day drugs are a lot more complex and demanding, both in terms of their physicochemical properties and biopharmaceutical and processing requirements than historically. In this chapter the formulation design of tablets and the interactions of the tabletting materials with processing routes will be discussed. A quality by design (QbD) approach is followed, with typical operating ranges described. Common tabletting issues will be reviewed and potential solutions proposed. Formulation for multilayer tablets, minitablets and continuous processing will also be discussed.