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CHAPTER 4

Poly(l-lysine)-Based Copolymers: Synthetic Strategies and Biomedical Applications

Poly(l-lysine)-based materials are extensively studied for potential biomedical applications. Among them, synthetic polymer–poly(l-lysine) hybrids are of particular interest due to the combination of advantageous properties characteristic of both components. In this chapter, the synthetic routes to poly(l-lysine)-based hybrid copolymers of various architectures are described. Contemporary synthetic methods such as controlled radical polymerization, controlled ring-opening polymerization of N-carboxyanhydrides (NCAs) and “click” chemistry as tools for the preparation of complex macromolecular architectures with poly(l-lysine) segments are presented. The potential applications of these materials in gene and drug delivery, tissue engineering and diagnostics are discussed.

Publication details


Print publication date
27 Nov 2014
Copyright year
2015
Print ISBN
978-1-84973-937-5
PDF eISBN
978-1-78262-010-5
ePub eISBN
978-1-78262-349-6
From the book series:
Polymer Chemistry Series