Carnosine Promotion of Wound Healing
A wound is an injury to the tissue that can be acute or chronic. Chronic wounds are associated with a pathologic condition like diabetes or obesity and are severe. Wounds, unless infected or ischemic, tend to heal naturally in well-defined and programmed phases. Alterations or impairment in the normal wound-healing process results in nonhealing wounds that engender enormous health-care expenditures with the total cost estimated at more than $3 billion per year. To address the growing global burden of acute and chronic wounds there is a need for effective healing agents. It is of high interest to investigate natural biomolecules as potential therapeutic targets because of their cost efficacy, being free from side effects and they can be derived from comestibles. Carnosine, the endogenous alanyl-histidine dipeptide most notably present in muscle and nerve tissues has been reported for its ability to accelerate wound healing. This chapter will review the findings of carnosine's role in wound healing.