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CHAPTER 7

The Biochemistry of Anserine and Carnosine Degrading Enzymes

Anserine and carnosine are structurally unusual imidazole dipeptides containing a non-α-amino acid at the N-terminus, and with a peptide bond resistant to hydrolysis by most of the known proteolytic enzymes. This chapter explores the most recent literature on vertebrate enzymes catalyzing the hydrolysis of these imidazole dipeptides, which are frequently named “anserinase” or “carnosinase”. It will focus on their history and discovery, distribution in vertebrate tissues, biochemical properties, biological roles, and their molecular evolution.

Publication details


Print publication date
13 Aug 2015
Copyright year
2015
Print ISBN
978-1-84973-890-3
PDF eISBN
978-1-78262-261-1
ePub eISBN
978-1-78262-655-8