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Chapter 4

Modelling the Human Respiratory System: Approaches for in Vitro Safety Testing and Drug Discovery

Respiratory research can be broken down into two main areas: (i) exposure to airborne substances (basic toxicology assessment); and (ii) respiratory diseases (understanding disease mechanisms and development of new therapeutics, including toxicological assessment). Both have suffered from inadequate and inaccurate models used to predict human toxicological end points. A growing need therefore exists for accurate in vitro models of the respiratory system, which accurately reflect the human lung situation in vivo. Advances in cell culture techniques and accessibility of human cells/tissues have resulted in the development of increasingly in vivo-like respiratory models. This chapter will focus on the development, advantages and disadvantages of these models and what the future holds for in vitro lung toxicology.

Publication details

https://doi.org/10.1039/9781782620136-00066
Print publication date
09 Dec 2014
Copyright year
2015
Print ISBN
978-1-84973-825-5
PDF eISBN
978-1-78262-013-6
ePub eISBN
978-1-78262-355-7
From the book series:
Drug Discovery