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Chapter 3

Translational Research in Pharmacology and Toxicology Using Precision-Cut Tissue Slices

In this chapter we discuss the application of human liver, intestine, lung and tumour precision-cut tissue slices (PCTS) as a translational ex vivo model in studies on ADME (absorption, distribution, metabolism and excretion) and toxicology of drugs, and for studies on diseases such as fibrosis in the liver and the intestine, obstructive lung diseases, viral infections and cancer. As the use of PCTS in research is steadily increasing it is impossible to give a fully comprehensive review of all applications of PCTS, but by highlighting some of the most important examples with a special emphasis on the application of human PCTS, we aim to show the extensive potential of this versatile technique in pathology and drug research.

Publication details

https://doi.org/10.1039/9781782620136-00038
Print publication date
09 Dec 2014
Copyright year
2015
Print ISBN
978-1-84973-825-5
PDF eISBN
978-1-78262-013-6
ePub eISBN
978-1-78262-355-7
From the book series:
Drug Discovery