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Potential Adverse Microbiological Effects of Antimicrobials

The potential adverse effects of antimicrobial drugs are not confined to their toxicological properties. These agents may induce adverse effects associated with their pharmacodynamic properties, including the induction of antimicrobial resistance. This is of particular significance when it occurs in organisms responsible for human disease such as Campylobacter. Studies using antimicrobial drugs and suitable bacterial populations may also be used to define microbiological acceptable daily intake (ADI) values in a manner analogous to the methods used for the calculation of toxicological ADI values. These values are important in elaborating maximum residue limits and similar indices for antimicrobial drugs. These issues, along with the experimental approaches used, are discussed in depth in this chapter.

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29 Nov 2012
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From the book series:
Issues in Toxicology