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Chapter 1

Designer bases, base pairs, and genetic sets: biochemical and biological activity

A chemical approach to synthetic biology allows researchers to build new chemical monomers and evaluate their activity in a biochemical and biological context. Here we describe the work our laboratory has done in developing alternative bases for DNA, including non-hydrogen bonding base analogs, which have been used to study stacking, hydrogen bonding, and steric requirements in duplex stability and enzyme recognition; and size-expanded DNA bases for the development of a non-Watson-Crick genetic set. The designed molecules are useful in basic science, allowing a better understanding of the functions of natural DNA and RNA, and are also contributing practical new tools for biology and medicine.

Publication details

Print publication date
13 Jun 2014
Copyright year
Print ISBN
ePub eISBN
From the book series:
SPR - Synthetic Biology