Chiral Recognition Using Fluorescent Boronic Acids Chemosensors
Enantioselective fluorescent recognition of chiral alpha-hydroxycarboxylic acids in aqueous solution remains a challenge for molecular chemosensors based on hydrogen bonding. To overcome this challenge, boronic acid-based chiral fluorescent chemosensors have been developed in recent years and enantioselective fluorescent recognition of the aforementioned analytes has been achieved in aqueous solutions. Different from the most conventional chemosensors, the intermolecular interactions, in other words, the binding between the boronic acid sensor and the analytes, are covalent bonds. The crucial scaffolds of these chiral sensors include a fluorophore, the arylboronic acid binding site and the linker between the two entities. New sensing mechanism and fluorescence reply profiles were observed with the chiral boronic acid sensors. The unanswered questions as well as the future development of the chiral fluorescent boronic acid sensors are also discussed.