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The Use of Cell Outer Membrane Mimetic Surfaces in Order to Obtain Clot Resistant Coatings

Phosphatidylcholines are a very interesting group of chemical compounds due to their ability to form organized structures similar to cell membranes. Such structures can be useful in counteracting adhesion of blood coagulation factors. This is why many scientists take attempts to combine phosphatidylcholines with new as well as already existing polymeric materials that are used in biomedical engineering. In this paper the current studies of the use of phospholipids for clot‐protecting materials have been shortly reviewed. In the further part of the paper authors' own study of a simple way of coating polyurethane with phosphatidylcholine in order to reduce the risk of blood clot formation was presented. In the study it was confirmed by analytical method that the procedure of coating fabrication was successful. The result of contact angle analysis suggests that phosphatidylcholine in the coating layer forms the structure of cell membrane. Cytotoxicity and blood compatibility tests confirmed that the final material is safe for mammalian cells and potentially useful in cardiovascular implants construction.

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10 Jun 2013
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