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CHAPTER 8

Discovery of NVP-AUY922

This chapter covers the identification and characterization of the novel Hsp90 inhibitor NVP-AUY922, which entered clinical trials in July 2007. The program leading to the identification of NVP-AUY922 (VER-52296) used complementary hit ID technologies such as HTS and fragment-based screening, relied heavily on structure-based design and required the design of new assays and probes to drive the compound optimization. In vivo characterization in tumor-bearing animals assisted in compound selection for pre-clinical studies.

Publication details


Print publication date
30 Oct 2013
Copyright year
2013
Print ISBN
978-1-84973-666-4
PDF eISBN
978-1-84973-968-9
From the book series:
Drug Discovery