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Acute Limit Oral Toxicity Study of 2,4,5-Trimethoxybenzaldehyde in Rats

2,4,5-TMBA is a bitter principle present in plants and has been shown to be a catalytic activity of cyclooxygenase-2. In previous study, we showed that 2,4,5-TMBA suppresses adipogenesis and promotes lipolysis. In this study, we conducted an acute limit oral toxicity test by gavaging 8-9 weeks old male Sprague-Dawley rats with 2000 mg/kg of 2,4,5-TMBA. The animals were observed for 7 days for any abnormal behavior or physiology. On day 8, all animals were sacrificed and subjected to visual and microscopic examination. The results indicate that rats gavaged with 2,4,5-TMBA at the dose of 2000 mg/kg did not develop significant toxicity during 7 days observation period. Evaluation of subchronic toxicity will need to be conducted before 2,4,5-TMBA is developed as anti-obesity nutraceutical.

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13 Mar 2013
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