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Parkinson’s Disease: Involvement of Iron and Oxidative Stress

Parkinson’s disease (PD) is the second most common neurodegenerative disorder affecting man after Alzheimer’s disease. The prevalence of PD in industrialized countries is approximately 0.3% of the whole population. The prevalence rises with age, which is a major risk factor in PD, from 1% in those over 60 years of age to almost 4% of the population over 80 years of age. The mean age of onset is approximately 60 years; however, 10% of cases are classified as young onset, occurring between 20 and 50 years of age. PD is more prevalent in men than women, with some reports suggesting a ratio of almost 3:1; this difference has been attributed to the neuroprotective effects of estrogen in females. The economic cost of PD to society is high, but gaining accurate figures is difficult due to differences in patient care between countries.

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24 Jul 2013
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