The present report on the oriented molecules covers the available literature published during the three year period ending in May 2012. The field of oriented molecules continues to be an area of significant interest with several experimental and computational techniques being continuously developed. The classification of the topics reported in this chapter essentially follows that of the earlier volume, and the available literature is presented under the following headings: Reviews, Theory and General Studies; New Techniques and Novel Orienting Media; Studies of Oriented Small Molecules Including Chiral Systems; Novel Mesophases and Orientational Order; Relaxation and Dynamic NMR Studies; Membranes and Molecules Oriented therein; Weak Ordering and Biomolecular Studies. The above classification is general. Some publications which are more relevant to a sub‐area of interest have been presented under the particular area rather than under the general heading. For example, methodologies and orienting media that target either chiral molecules or membranes or proteins are given under the corresponding category, rather than under the general topic of techniques and orienting media.