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CHAPTER 7

Chemical Degradation of Biological Drugs

Because the overwhelming majority of biological drugs are protein/peptide drugs, the main focus of this chapter is placed on the mechanisms of protein/peptide degradation, such as peptide bond hydrolysis, deamidation, side chain oxidation, disulfide bridge decomposition, β-elimination, and crosslinking, and so on. A few representative degradation mechanisms for carbohydrate- and nucleic acid-based biological drugs are also discussed.

Publication details


Print publication date
25 Sep 2012
Copyright year
2012
Print ISBN
978-1-84973-421-9
PDF eISBN
978-1-84973-536-0
From the book series:
Drug Discovery