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Chapter 3

Nanopillars, Nanowires and Nanoballs for DNA and Protein Analysis

Recent development of nanofluidic devices using nanopillars, nanowires, and nanoballs for high-performance biomolecules analysis are reviewed in this chapter. Two approaches, “top-down” fabrication techniques and “bottom-up” self-assemble techniques, were applied to construct nanospace inside microchannels, and various biomolecules including DNA, RNA and proteins were successfully separated within a few seconds. These separation techniques enabled high throughput analysis that had never achieved by natural or synthetic polymers and explored a new bioanalytical field based on molecular dynamics in nanospace. Hybrid use of the both approaches might be promising for future home diagnostic devices and clinical applications.

Print publication date: 18 Nov 2016
Copyright year: 2017
Print ISBN: 978-1-84973-404-2
PDF eISBN: 978-1-84973-523-0
ePub eISBN: 978-1-78262-958-0