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Iontophoretic Delivery of Glycomimetics-A New Approach for the Treatment of Inflammatory Skin Diseases

A key event in the inflammatory response is the recruitment of leukocytes from the microcirculation to the inflamed tissue through endothelial-dependent mechanisms that include leukocyte tethering and rolling, activation, firm adhesion and diapedesis to the interstitium. Leukocyte tethering and rolling along the endothelial surface is mediated by a family of carbohydrate-binding proteins (E-, P- and L-selectins). While L-selectin is constitutively expressed on the surface of leukocytes, expression of E- and P-selectin is upregulated on the endothelial surface during inflammation.

Publication details


Print publication date
06 Dec 2013
Copyright year
2014
Print ISBN
978-1-84973-398-4
PDF eISBN
978-1-84973-463-9
From the book series:
Issues in Toxicology