Chapter 5: Neurotoxicity Biomarkers in Experimental Acute and Chronic Brain Injury
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Published:16 May 2012
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Series: Drug Discovery
U. I. Danilenko, G. A. Khunteev, A. Bagumyan, and G. A. Izykenova, in Biomarkers for Traumatic Brain Injury, ed. S. Dambinova, R. L. Hayes, and K. K. Wang, The Royal Society of Chemistry, 2012, ch. 5, pp. 87-105.
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Mild traumatic brain injury (TBI) is believed to induce glutamate-mediated neurotoxicity, causing alterations in ionotropic glutamate receptors with subsequent brain injury sequelae. In this chapter, the possibility of peptide fragments of ionotropic glutamate receptors detected in the blood of rodents to serve as autoantigens and autoantibodies is explored using experimental models of mild brain injury. Effects of potential endogenous peptide inhibition of ionotropic glutamate receptors for preventive treatment of brain injury are also explored.
