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Chapter 5

Docking, Screening and Selectivity Prediction for Small-molecule Nuclear Receptor Modulators

Nuclear receptors (NRs) represent a family of ligand-dependent transcription factors, united by common functional mechanism and domain architecture. At least 13% of marketed drugs target NRs.1 The two key domains, the ligand-binding domain (LBD) and the DNA-binding domain (DBD), are conserved in mos...
Print publication date: 02 Nov 2012
Copyright year: 2013
Print ISBN: 978-1-84973-364-9
PDF eISBN: 978-1-84973-535-3
From the book series:
Drug Discovery