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Chapter 4

Chemoinformatic Approaches to Target Identification

Many on-market drugs bind to multiple protein targets at therapeutic concentrations. Such ‘off-target’ binding contributes to drug efficacy and also to adverse drug effects. In some cases, newly identified off-targets may represent drug repositioning opportunities. This chapter presents chemoinformatic methods used to predict drug off-target binding on a broad scale, in the context of their application to target identification and target-specific toxicity.

Publication details

https://doi.org/10.1039/9781849734912-00050
Print publication date
12 Apr 2012
Copyright year
2012
Print ISBN
978-1-84973-362-5
PDF eISBN
978-1-84973-491-2
From the book series:
Drug Discovery