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Chapter 11

Anthelmintic Discovery for Human Infections

Recognition that neglected tropical diseases due to human helminth infection contribute greatly to the cycle of poverty that plagues poor regions of the world has spurred recent investment in the identification of new and better drugs to control or eliminate these pathogens. None of the anthelmintics used in humans can be considered ‘optimal’, especially in the context of mass drug administration, although their deployment has led to undeniable gains in controlling the pathology and transmission of these infections. A few drugs that have been developed and registered for uses in veterinary medicine or for other human infections may have applications for helminthiases, but new drugs are still needed. Early discovery pipelines for these diseases are not robust, and renewed efforts at lead identification and development are necessary for sustainable control and potential elimination of these pathogens.

Print publication date: 04 Nov 2011
Copyright year: 2012
Print ISBN: 978-1-84973-192-8
PDF eISBN: 978-1-84973-349-6
From the book series:
RSC Drug Discovery