Jump to main content
Jump to site search

All chapters
Previous chapter Next chapter

Chapter 6

Role of Metabolism in the Bioactivation/Detoxification of Food Contaminants

Various compounds of either natural or synthetic origin mimic or interfere with the biological activity of hormones. Whereas some of these compounds are deactivated by their metabolism, others, such as the isoflavone daidzein, the pesticides vinclozolin and methoxychlor, the polychlorinated biphenyls and the polybrominated diphenyl ethers require metabolic activation prior to exhibiting endocrine disrupting effects. This chapter describes the metabolic pathways of several endocrine disruptors and indicates the role of these pathways in the bioactivation/detoxification of these compounds, resulting in increases or decreases in hormonal activity. It focuses not only on the interactions of metabolites with various nuclear receptors, but also with the effects of biotransformation products on steroidogenesis and hormone metabolism.

Publication details

https://doi.org/10.1039/9781849732970-00093
Print publication date
04 Nov 2011
Copyright year
2012
Print ISBN
978-1-84973-189-8
PDF eISBN
978-1-84973-297-0
From the book series:
Issues in Toxicology