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Ion Channel Drug Discovery: a Historical Perspective

Widely regarded as attractive drug targets for many therapeutic applications, worldwide sales of modulators of ion channel function are estimated at US$12 billion. With over 400 genes encoding for more than 300 members of the ion channel family, often referred to genomically as the “chanome” or “channelome”, it is perhaps surprising that less than twenty percent of ion channels are currently commercially exploited. Historically, drug discovery efforts on ion channel targets have progressed without the benefit of molecular and structural information, but with recent advances in the area of target validation, screening technologies and optimization paradigms, increasingly utilizing structural-based design, natural products and antibody approaches, this offers the exciting prospect of a more productive era of ion channel drug discovery.

Print publication date: 18 Sep 2014
Copyright year: 2015
Print ISBN: 978-1-84973-186-7
PDF eISBN: 978-1-84973-508-7
ePub eISBN: 978-1-78262-307-6
From the book series:
Drug Discovery