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Chapter 1

The Kinome and its Impact on Medicinal Chemistry

The “Kinome” describes the protein kinase component of the human genome, exhaustively compiled in 2002 by Manning et al.1 A search of available human sequence sources using a hidden Markov model identified 478 ePK (eukaryotic protein kinase) genes, 491 ePK domains, and 40 “atypical” protein kinases....

Publication details

Print publication date
06 Dec 2011
Copyright year
Print ISBN
From the book series:
Drug Discovery