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Chapter 16

Monographs of most Frequent Co-Crystal Formers

In terms of preparation of co-crystals, both the screening and the supramolecular synthon-based retrosynthetical approaches benefit from better knowledge of the physicochemical properties of co-crystal formers. This chapter aims to provide a listing of frequently encountered candidates. Besides more classical properties (pKa, melting point, solubility), powder X-ray diffractograms have been simulated in the most representative and informative cases. These characteristics should be affected upon formation of co-crystals and are thus a guide to the further identification of original formulations. The potential polymorphism of the co-crystal former is also flagged and selected examples of co-crystals are provided.

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Print publication date
14 Nov 2011
Copyright year
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From the book series:
Drug Discovery