Concluding Remarks using Piracetam as a Learning Model
Selected structures of co-crystals involving Piracetam illustrate the possibility of formation of co-crystals of an API using both hydrogen bonds and/or metal coordination. Distinct patterns of interactions (supramolecular synthons) within the crystal packing are discussed. Synthesis of an original co-crystal between Brivaracetam, a structurally related analog of Piracetam, and MgCl
On this basis, and with the many examples that have been provided throughout the different chapters of the book, it is suggested that most (if not all) APIs contain in their structure the functional group(s) that could lead to co-crystallisation, and hence to the expansion of their pharmaceutical space. This exciting perspective fully justifies both academic and industrial interest in these systems.