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Chapter 11

Co-crystal Solubility and Thermodynamic Stability

Co-crystals play a significant role in solving bioavailability problems because they have the ability to fine tune solubility and delivery of drugs. Understanding the link between the structure/composition of co-crystals and their solution properties is important, so that co-crystal and formulation conditions can be selected on a rational basis. This chapter presents the thermodynamic factors that influence co-crystal solubility, the parameters that determine co-crystal stability, and experimental methods that overcome the difficulties of co-crystal conversion to less soluble phases.

Publication details


Print publication date
14 Nov 2011
Copyright year
2012
Print ISBN
978-1-84973-158-4
PDF eISBN
978-1-84973-350-2
From the book series:
Drug Discovery