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Chapter 8

Application of Mechanochemistry in the Synthesis and Discovery of New Pharmaceutical Forms: Co-crystals, Salts and Coordination Compounds

In the past decade mechanochemical methodologies, such as neat grinding and liquid-assisted grinding, have been demonstrated to be a highly efficient means of both synthesising and screening for pharmaceutical co-crystals. This chapter provides an overview of these mechanochemical methodologies, their applications to date, an overview of mechanistic details and a brief comparison with more conventional co-crystallisation methods based on solution crystallisation and slurrying. In addition to the use of mechanosynthesis in the context of pharmaceutical co-crystals, its application for pharmaceutical salt synthesis and screening is also described, as well as recent applications in the synthesis of metal–organic derivatives.

Publication details

Print publication date
14 Nov 2011
Copyright year
Print ISBN
From the book series:
Drug Discovery