Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


All chapters
Previous chapter Next chapter

Chapter 3

Role of Fluorine in Weak Interactions in Co-crystals

The presence of the C–F bond (commonly referred to as organic fluorine) in a large number of pharmaceutically relevant compounds suggests that it may be used in the production of novel salts and co-crystals that have intermolecular interactions involving fluorine. There is an ongoing debate in this context as fluorine is characterized by its high electronegativity, relatively small size and very low polarizability. The propensity of hydrogen to participate in generating highly directional and energetically stable hydrogen bonds has been exploited in the design of co-crystals and salts of many pharmaceutical compounds. A direct extension of this property to fluorine, however, is not plausible and thus intermolecular interactions involving fluorine must be quantified. Recent results and new approaches designed to evaluate organic fluorine which provide useful inputs for the design of co-crystals and salts are discussed in this chapter.

Publication details


Print publication date
14 Nov 2011
Copyright year
2012
Print ISBN
978-1-84973-158-4
PDF eISBN
978-1-84973-350-2
From the book series:
Drug Discovery